It is difficult to overstate the impact that technology has had on us, transforming our ways of life and making us more connected than ever before. Where once you had to take days or months to reach the other side of the world, now you can fly from London to Hong Kong in a matter of hours. Where not so long ago in human history we could only rely on candlelight, now artificial lighting is so ubiquitous that we take them for granted. The demand for ever faster connectedness is having unprecedented effects on our circadian rhythms: jet lag is perhaps the best known example of one way in which the body clock gets disrupted, but the problems associated with electricity are arguably even greater, precisely because our 24/7 society is completely dependent on it in order to function. Body clock disruption has been implicated in a whole range of diseases, from depression to cancer, so it is now more urgent than ever before that scientists try to understand the mechanisms of the body clock, so we are in a better position to fix it when it does go wrong.
In this episode of The Provocateur I talk to Aarti Jagannath, a research fellow at the Nuffield Department of Clinical Neurosciences at the University of Oxford, to help us unravel the mysteries of the body clock. We discuss the fundamentals of the body clock and what happens when it gets disrupted in a whole range of scenarios, from shift work to divers undergoing decompression to students pulling the occasional all-nighter. We also talk about the ways in which neuroscientists are trying to figure out how to reset our natural circadian cycle and even how some biologists are coming up with innovative treatments that exploit the body clock to better target cancer cells.
You can listen to the podcast here: